Gluten Intolerance: Symptoms, Test, Non-Celiac Gluten Sensitivity (2024)

What is gluten intolerance?

You may have a gluten intolerance if you get sick after eating gluten, a type of protein. You might feel tired, nauseous or bloated. Another name for gluten intolerance is non-celiac gluten sensitivity (NCGS).

Advertisem*nt

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

What is gluten?

Gluten is a protein found in wheat, barley, rye and other grains. It’s in a lot of common foods and drinks, including pasta, cereal and beer. Gluten can also be in things like vitamins, cosmetics and even certain medications.

Are gluten intolerance and celiac disease the same thing?

Gluten intolerance and celiac disease are different. People with celiac disease have an autoimmune response to gluten. This means their bodies try to fight against gluten as if it were a virus. This reaction causes inflammation and damage to their digestive tracts. Celiac disease is the result of an abnormal gene. People with celiac disease also have high levels of certain antibodies in their blood, which are substances that fight gluten.

Gluten sensitivity and celiac disease cause a lot of the same symptoms. But people with gluten sensitivity don’t have an abnormal gene or antibodies in their blood.

Advertisem*nt

Is gluten intolerance a gluten allergy?

An intolerance and a food allergy aren’t the same. A food allergy, such as a wheat allergy, is when your immune system overreacts after you eat a certain food. An allergy might cause itching, vomiting or shortness of breath. Gluten intolerance isn’t an allergy to gluten.

Who gets gluten intolerance?

Anyone can have a gluten intolerance, though it’s more common in women. Some people are born with a gluten intolerance; others develop it later in life.

Advertisem*nt

How common is gluten intolerance?

Research suggests that about 6% of the U.S. population is gluten intolerant. It’s more common than celiac disease, which affects about 1% of the population.

Gluten Intolerance: Symptoms, Test, Non-Celiac Gluten Sensitivity (2024)

FAQs

Gluten Intolerance: Symptoms, Test, Non-Celiac Gluten Sensitivity? ›

Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing foods in the absence of celiac disease and wheat allergy.

Can you be gluten sensitive but not celiac? ›

Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing foods in the absence of celiac disease and wheat allergy.

How do you test for gluten intolerance if you are not celiac? ›

How Do Doctors Test for Gluten Sensitivity? Currently, there are no recommended methods to test for non-celiac gluten sensitivity. It is a diagnosis of exclusion, which means that other causes, including celiac disease and wheat allergy, need to be ruled out and the patient needs to feel better on the gluten-free diet.

What is a reason that non-celiac gluten sensitivity is difficult to diagnose? ›

Absence of reliable biomarkers and the fact that some people do not have digestive symptoms make the recognition and diagnosis of non-celiac gluten sensitivity (NCGS) difficult. Diagnosis is generally performed only by exclusion criteria.

What is the most accurate way to diagnose gluten sensitivity? ›

For adults, doctors typically recommend both blood tests and biopsies, in which tissue samples are examined under a microscope, to confirm the diagnosis.

What is often mistaken for gluten intolerance? ›

The symptoms of gluten intolerance may also resemble those of a wheat allergy or intestinal conditions such as irritable bowel syndrome (IBS). Experts estimate that 10–15% of adults in the U.S. have IBS symptoms.

What are the neurological symptoms of non-celiac gluten sensitivity? ›

There's no question that gluten can affect your neurological system: people with both celiac disease and non-celiac gluten sensitivity report symptoms that range from headaches and brain fog to peripheral neuropathy (tingling in your extremities).

Can you have gluten antibodies and not have celiac? ›

People with non-celiac gluten sensitivity (NCGS) show an immune response distinct from celiac disease. New research from Columbia University revealed differences in the antibodies present, adding evidence that NCGS involves a different kind of inflammation in the gut in response to gluten.

Can you test negative for celiac disease and still have gluten intolerance? ›

While it is very rare, it is possible for someone with celiac disease to have negative antibody test results. If your tests were negative, but you continue to experience symptoms, consult your physician and undergo further medical evaluation.

How do I test myself for gluten intolerance? ›

There's no definitive test for gluten sensitivity. If you suspect your symptoms are related to gluten in the foods you eat, the best treatment is to change your diet. Since gluten is the protein found in wheat, barley, and rye, these are foods you'd need to eliminate.

What autoimmune disease causes gluten sensitivity? ›

Autoimmune Reaction to Gluten: Celiac Disease

When someone with celiac disease consumes food with gluten, the immune system reacts and attacks the villi of their intestines. These villi are little fingerlike projections in the intestinal lining that absorb nutrients and energy from the foods we eat.

What does NCGS feel like? ›

Signs and symptoms of NCGS

Bloating or gas. Nausea. Cramping. Diarrhea and/or constipation.

How do you reverse non-celiac gluten sensitivity? ›

There's no cure for gluten intolerance. But most people find relief from symptoms by following a gluten-free diet. You should work with your healthcare provider and a dietitian to plan your diet. You can also ask your healthcare provider about adding probiotics to your diet.

Can a gluten intolerance test be wrong? ›

To get a reliable result you should have been eating gluten for more than one meal a day for six weeks, so it's easy to see how someone could fall below this. If you weren't eating gluten at the time of your blood test, or you had limited your gluten intake, you may have received an inaccurate result.

Can you test for non-celiac gluten sensitivity? ›

There is no test to check for Non-Celiac Gluten Sensitivity; it is diagnosed by a doctor who considers the signs and symptoms, negative celiac disease testing, and improvement after a gluten-free diet.

What is the rapid test for gluten intolerance? ›

GlutenCHECK is a rapid test for use at home to detect the presence of IgA tissue transglutaminase antibodies (tTG) in whole blood. GlutenCHECK is suitable for both, an initial diagnosis of gluten intolerance as well as a therapy follow-up. a-tTG-IgA antibody level should fall when gluten is removed from the diet.

What is the difference between celiac disease and gluten sensitivity? ›

Celiac disease is an autoimmune disorder, whereas gluten intolerance is a sensitivity,” says Northwestern Memorial Hospital Clinical Dietitian Bethany Doerfler, MS, RD, LDN. “NCGS does not typically have a full negative impact on overall health like celiac disease can.”

Is gluten sensitivity an autoimmune disease? ›

Gluten sensitivity

However, researchers know for a fact that it isn't an autoimmune disease. There is, therefore, a clear link between gluten and autoimmune disease in the sense that people with coeliac disease, an autoimmune disease, should avoid the protein found in wheat, barley and rye at all costs.

What can mimic celiac disease? ›

Despite awareness efforts, celiac disease is often confused with other gluten-related disorders — like non-celiac gluten sensitivity (NCGS) or a wheat allergy. Both seem similar to celiac disease, but are different conditions.

Does gluten cause inflammation if you don't have celiac? ›

In fact, many gluten-containing foods – like certain kinds of whole grains,– have been associated with reducing inflammation. So, this means that gluten doesn't cause inflammation for everyone. Celiac disease is an autoimmune disorder where consuming gluten damages the small intestine.

Top Articles
Latest Posts
Article information

Author: Nathanial Hackett

Last Updated:

Views: 6137

Rating: 4.1 / 5 (72 voted)

Reviews: 87% of readers found this page helpful

Author information

Name: Nathanial Hackett

Birthday: 1997-10-09

Address: Apt. 935 264 Abshire Canyon, South Nerissachester, NM 01800

Phone: +9752624861224

Job: Forward Technology Assistant

Hobby: Listening to music, Shopping, Vacation, Baton twirling, Flower arranging, Blacksmithing, Do it yourself

Introduction: My name is Nathanial Hackett, I am a lovely, curious, smiling, lively, thoughtful, courageous, lively person who loves writing and wants to share my knowledge and understanding with you.